| Active Roster | ||||||||
|---|---|---|---|---|---|---|---|---|
| Name | No. | Pos. | Ht. | Wt. | Age | Exp. | League Entry | College |
| Akers, David | 2 | K | 5-10 | 200 | 37 | 13 | UDFA (Panthers-97) | Louisville Cardinals |
| Boone, Alex | 75 | OT | 6-07 | 328 | 24 | 2 | UDFA (49ers-09) | Ohio State Buckeyes |
| Bowman, Navorro | 53 | ILB | 6-00 | 242 | 23 | 2 | D3 91st (49ers-10) | Penn State Nittany Lions |
| Brock, Tramaine | 26 | CB | 5-10 | 197 | 23 | 2 | UDFA (49ers-10) | Belhaven College Blazers |
| Brooks, Ahmad | 55 | OLB | 6-04 | 259 | 27 | 6 | D3 Supp. (Bengals-06) | Virginia Cavaliers |
| Brown, Tarell | 25 | CB | 5-10 | 190 | 27 | 5 | D5 147th (49ers-07) | Texas Longhorns |
| Costanzo, Blake | 51 | ILB | 6-02 | 235 | 27 | 4 | UDFA (Jets-06) | Lafayette College Leopards |
| Crabtree, Michael | 15 | WR | 6-01 | 214 | 24 | 3 | D1 10th (49ers-09) | Texas Tech Red Raiders |
| Culliver, Chris | 29 | CB | 6-00 | 201 | 23 | R | D3 80th (49ers-11) | South Carolina Gamecocks |
| Davis, Anthony | 76 | OT | 6-06 | 325 | 22 | 2 | D1 11th (49ers-10) | Rutgers Scarlet Knights |
| Davis, Vernon | 85 | TE | 6-03 | 256 | 28 | 6 | D1 6th (49ers-06) | Maryland Terrapins |
| Dixon, Anthony | 24 | RB | 6-00 | 233 | 24 | 2 | D6 173rd (49ers-10) | Mississippi State Bulldogs |
| Dobbs, Demarcus | 96 | DE | 6-02 | 285 | 24 | R | UDFA (49ers-11) | Georgia Bulldogs |
| Ginn, Ted | 19 | WR | 5-11 | 180 | 26 | 5 | D1 9th (Dolphins-07) | Ohio State Buckeyes |
| Goldson, Dashon | 38 | S | 6-02 | 205 | 27 | 5 | D4 126th (49ers-07) | Washington Huskies |
| Gooden, Tavares | 56 | ILB | 6-01 | 235 | 27 | 4 | D3 71st (Ravens-08) | Miami (Fla.) Hurricanes |
| Goodwin, Jonathan | 59 | C | 6-03 | 318 | 33 | 10 | D5 154th (Jets-02) | Michigan Wolverines |
| Gore, Frank | 21 | RB | 5-09 | 217 | 28 | 7 | D3 65th (49ers-05) | Miami (Fla.) Hurricanes |
| Grant, Larry | 54 | ILB | 6-01 | 235 | 26 | 4 | D7 214th (49ers-08) | Ohio State Buckeyes |
| Haralson, Parys | 98 | OLB | 6-00 | 250 | 28 | 6 | D5 140th (49ers-06) | Tennessee Volunteers |
| Hastings, Joe | 13 | WR | 6-00 | 185 | 24 | R | UDFA (49ers-11) | Washburn Ichabods |
| Hunter, Kendall | 32 | RB | 5-07 | 199 | 23 | R | D4 115th (49ers-11) | Oklahoma State Cowboys |
| Iupati, Mike | 77 | OG | 6-05 | 331 | 24 | 2 | D1 17th (49ers-10) | Idaho Vandals |
| Jean-Francois, Ricky | 95 | DT | 6-03 | 295 | 25 | 3 | D7 244th (49ers-09) | LSU Tigers |
| Jennings, Brian | 86 | LS | 6-05 | 245 | 35 | 12 | D7 230th (49ers-00) | Arizona State Sun Devils |
| Jones, Colin | 43 | S | 6-00 | 205 | 24 | R | D6 190th (49ers-11) | TCU Horned Frogs |
| Kaepernick, Colin | 7 | QB | 6-05 | 233 | 24 | R | D2 36th (49ers-11) | Nevada Wolf Pack |
| Kilgore, Daniel | 67 | C | 6-03 | 304 | 24 | R | D5 163rd (49ers-11) | Appalachian State Mountaineers |
| Lee, Andy | 4 | P | 6-00 | 206 | 29 | 8 | D6 188th (49ers-04) | Pittsburgh Panthers |
| McDonald, Ray | 91 | DE | 6-03 | 276 | 27 | 5 | D3 97th (49ers-07) | Florida Gators |
| Miller, Bruce | 49 | FB | 6-02 | 259 | 24 | R | D7 211th (49ers-11) | UCF Golden Knights |
| Norris, Moran | 44 | FB | 6-01 | 250 | 33 | 11 | D4 115th (Saints-01) | Kansas Jayhawks |
| Peelle, Justin | 81 | TE | 6-04 | 250 | 32 | 10 | D4 103rd (Chargers-02) | Oregon Ducks |
| Person, Mike | 78 | OG | 6-05 | 296 | 23 | R | D7 239th (49ers-11) | Montana State Bobcats |
| Rachal, Chilo | 62 | OG | 6-04 | 319 | 25 | 4 | D2 39th (49ers-08) | USC Trojans |
| Rogers, Carlos | 22 | CB | 6-01 | 195 | 30 | 7 | D1 9th (Redskins-05) | Auburn Tigers |
| Smith, Aldon | 99 | OLB | 6-05 | 255 | 22 | R | D1 7th (49ers-11) | Missouri Tigers |
| Smith, Alex | 11 | QB | 6-04 | 212 | 27 | 7 | D1 1st (49ers-05) | Utah Utes |
| Smith, Justin | 94 | DE | 6-04 | 275 | 32 | 11 | D1 4th (Bengals-01) | Missouri Tigers |
| Smith, Reggie | 30 | S | 6-01 | 199 | 25 | 4 | D3 75th (49ers-08) | Oklahoma Sooners |
| Snyder, Adam | 68 | OG | 6-05 | 316 | 30 | 7 | D3 94th (49ers-05) | Oregon Ducks |
| Sopoaga, Isaac | 90 | DT | 6-02 | 321 | 30 | 8 | D4 104th (49ers-04) | Hawaii Rainbows |
| Spencer, Shawnte | 36 | CB | 6-00 | 176 | 29 | 8 | D2 58th (49ers-04) | Pittsburgh Panthers |
| Spillman, C.J. | 27 | S | 6-00 | 196 | 25 | 3 | UDFA (Chargers-09) | Marshall Thundering Herd |
| Staley, Joe | 74 | OT | 6-05 | 306 | 27 | 5 | D1 28th (49ers-07) | Central Michigan Chippewas |
| Swain, Brett | 18 | WR | 6-00 | 200 | 26 | 3 | D7 217th (Packers-08) | San Diego State Aztecs |
| Tolzien, Scott | 3 | QB | 6-02 | 209 | 24 | R | UDFA (Chargers-11) | Wisconsin Badgers |
| Walker, Delanie | 46 | TE | 6-00 | 237 | 27 | 6 | D6 175th (49ers-06) | Central Missouri State Mules |
| Whitner, Donte | 31 | S | 5-11 | 205 | 26 | 6 | D1 8th (Bills-06) | Ohio State Buckeyes |
| Williams, Ian | 93 | NT | 6-01 | 305 | 22 | R | UDFA (49ers-11) | Notre Dame Fighting Irish |
| Williams, Kyle | 10 | WR | 5-11 | 186 | 23 | 2 | D6 206th (49ers-10) | Arizona State Sun Devils |
| Williams, Madieu | 20 | S | 6-01 | 203 | 30 | 8 | D2 56th (Bengals-04) | Maryland Terrapins |
| Willis, Patrick | 52 | ILB | 6-01 | 242 | 27 | 5 | D1 11th (49ers-07) | Mississippi Rebels |
| Injured Reserve | ||||||||
| Name | No. | Pos. | Ht. | Wt. | Age | Exp. | League Entry | College |
| Bogan, Dontavia | 9 | WR | 6-00 | 187 | 23 | R | UDFA (49ers-11) | South Florida Bulls |
| Byham, Nate | 82 | TE | 6-04 | 268 | 23 | 2 | D6 182nd (49ers-10) | Pittsburgh Panthers |
| Holcomb, Curtis | 41 | CB | 5-10 | 190 | 23 | R | D7 250th (49ers-11) | Florida A&M Rattlers |
| Morgan, Josh | 84 | WR | 6-00 | 219 | 26 | 4 | D6 174th (49ers-08) | Virginia Tech Hokies |
| Tukuafu, Will | 92 | DE | 6-03 | 272 | 28 | 1 | UDFA (Seahawks-10) | Oregon Ducks |
| Reserve - Future | ||||||||
| Name | No. | Pos. | Ht. | Wt. | Age | Exp. | League Entry | College |
| Beeler, Chase | 61 | TE | 6-03 | 285 | 25 | R | UDFA (49ers-11) | Stanford Cardinal |
| Chisolm, Garrett | OG | 6-05 | 312 | 23 | R | UDFA (Dolphins-11) | South Carolina Gamecocks | |
| Hall, Derek | 71 | OT | 6-05 | 307 | 24 | R | UDFA (49ers-11) | Stanford Cardinal |
| LeGree, Mark | S | 6-00 | 211 | 22 | R | D5 156th (Seahawks-11) | Appalachian State Mountaineers | |
| Matthews, John | 83 | WR | 6-00 | 200 | 25 | 2 | UDFA (Colts-09) | University of San Diego Toreros |
| Nelms, Cory | 23 | CB | 6-00 | 195 | 23 | R | UDFA (49ers-11) | Miami (Fla.) Hurricanes |
| Nelson, Kyle | LS | 6-02 | 240 | 23 | R | UDFA (Saints-11) | New Mexico State Aggies | |
| Reuland, Konrad | 88 | TE | 6-04 | 260 | 24 | R | UDFA (49ers-11) | Stanford Cardinal |
| Wiggins, Kenny | OT | 6-06 | 314 | 23 | R | UDFA (49ers-11) | Fresno State Bulldogs | |
| Wilhoite, Michael | 57 | OLB | 6-00 | 240 | 25 | R | UDFA (49ers-11) | Washburn Ichabods |